Being so close to Mexican territory, it's natural that San Diego would be recognized for its exceptionally Mexican food; and it's true that there's a taqueria on almost every corner. For example, the El Zarape Mexican Restaurant serves a sinfully good scallop burrito.
But don't consider this town's culinary panache stops with pico de gallo. Various sushi spots and additional restaurants acquire good advantage of the fresh catches approaching in from the Pacific each morning. Zenbu Sushi Bar and Restaurant attends a great house roll and whatever sashimi's the freshest. The Oceanaire Seafood Room serves a halibut that's superb any way they cook it.
Majority of every neighborhood has a one-year food event during which area restaurants provide tasting samples. Downtown is known for its many Italian joints, like the gorgonzola-pesto gnocchi at De Medici's (815 5th Ave) is some of the best in town. Try the Branzino sea bass in morel mushroom sauce at Buon Appetito (1609 India St).
San Diego is quick becoming a restaurant mecca, powered by the inventiveness and youth of the chefs who are drawn to the relaxed environment, enthusiastic patrons, and generosity of local ingredients, including seafood.